Endocrine Abstracts

(Aims) Regulation of humoral immunity is important to develop vaccines for infectious disease and cancer. However, human and mouse humoral immune systems contain different molecular mechanisms, and the evaluation of efficacy is difficult in the pre-clinical investigation. Humanized mice with reconstructed human immune system are useful for drug discovery of molecular-targeted drugs related to the immune system, and evaluation of antibody production by vaccines. The development...

During pregnancy, levels of pregnancy-related proteins and hormones such as progesterone (P4), estrogen, and glucocorticoids (GC) increase. Although the regulatory mechanisms of P4 production in the placenta are not completely understood, studies using mouse models have demonstrated that P4 induces immunosuppression using a GC receptor-dependent pathway, suggesting that both it has been suggested that steroid hormones have a similar effect. Understanding the orchestrated role ...